Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women
Menée à partir de données portant sur 592 patientes afro-américaines atteintes d'un cancer épithélial de l'ovaire de stade invasif, cette étude de cohorte analyse l'association entre une exposition à des facteurs liés à une inflammation (notamment une alimentation pro-inflammatoire) et la survie
Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.