Sexual Health Outcomes Among Adolescent and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis
A partir d'une revue systématique de la littérature publiée de 2000 à 2022 (8 articles, 9 038 patients), cette méta-analyse évalue la santé sexuelle des adolescents et jeunes adultes ayant survécu à un cancer (âge : 15-39 ans)
Sexual health outcomes (SHO), which entail the physical, emotional, mental and social impacts, are an important consideration for adolescent and young adults (AYA, ages 15-39) affected by cancer. The objective of this systematic review and meta-analysis is to summarize the current literature and evaluate AYA cancer impacts on SHO.EMBASE and MEDLINE were searched from 01/01/2000 to 09/28/2022 to identify epidemiologic studies that used an analytic observational design, included individuals with AYA cancer and non-cancer controls, and evaluated SHO. Odds ratios and prevalence ratios were calculated; random effects models were used to obtain pooled measures where possible.Of 2621 articles, 8 were included that investigated 23 SHO in 9,038 AYA cancer patients. Based on the sexual response cycle, outcomes were categorized as those occurring among males (desire = 1, arousal = 1, orgasm = 4, other = 3) and females (desire = 2, arousal = 1, orgasm = 2, pain = 6, other = 3). It was feasible to conduct meta-analysis for 3 female SHO and 5 male SHO. There were associations between AYA cancer and 3 SHO: vaginal dryness (pOR 3.94; 95% CI: 2.02, 7.70), ejaculatory dysfunction (pOR 3.66; 95% CI: 2.20, 6.08), and testosterone level (pooled mean difference = -2.56 nmol/liter; 95% CI: -3.46, -1.66; p = .00001).This study found increased ejaculatory dysfunction and reduced testosterone levels in male AYA cancer patients and increased vaginal dryness in female AYA cancer patients, highlighting the need for sexual health resources in this population.
JNCI Cancer Spectrum 2023