Association between Vitamin B6 and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Epidemiological Studies
A partir d'une revue systématique de la littérature publiée jusqu'en mai 2023 (12 études, 5 692 patients), cette méta-analyse évalue l'association entre la consommation de vitamine B6 et le risque de cancer gastrique
Inconsistent findings have emerged from epidemiological research investigating the association between vitamin B6 and the risk of gastric cancer. To obtain a more precise assessment, we conducted a comprehensive search of published data and performed a meta-analysis. PubMed, Web of Science, EMBASE and Cochrane Library databases were systematically searched. A total of 12 studies (5 prospective cohort and 7 case?control studies) involving 5,692 cases and 814,157 participants were included in the meta-analysis. The results showed that high intake of vitamin B6 may reduce the odds of gastric cancer (OR = 0.83, 95% CI: 0.73?0.95, p?=?0.006). However, this association was only observed in the case?control studies (OR = 0.68, 95% CI: 0.51?0.89, p?=?0.006) but not in the cohort studies (RR = 1.01, 95% CI: 0.94?1.08, p?=?0.819). Additionally, the negative association between vitamin B6 intake and gastric cancer risk was found in the United States of America (OR = 0.71, 95% CI: 0.62?0.82, p?=?10?4), but not in Europe (OR = 0.88, 95% CI: 0.74?1.05, p?=?0.169) or the other regions (OR = 0.86, 95% CI: 0.66?1.13, p?=?0.280). In conclusion, there is not sufficient evidence to assume that vitamin B6 intake is associated with gastric cancer risk, which needs further confirmation.
Nutrition and Cancer 2023