Mitochondria-targeting Cu3VS4 nanostructure with high copper ionic mobility for photothermoelectric therapy
Menée in vitro et à l'aide d'un modèle murin, cette étude met en évidence l'intérêt de nanoparticules cubiques (constituées de cuivre, de soufre, de vanadium et de triphénylphosphine) capables de supprimer les cellules tumorales en générant, sous l'effet d'un laser en proche infrarouge, de la chaleur, des radicaux superoxydes et du NAD+ dans les mitochondries (oxydation du NADH par effet Seebeck)
Thermoelectric therapy has emerged as a promising treatment strategy for oncology, but it is still limited by the low thermoelectric catalytic efficiency at human body temperature and the inevitable tumor thermotolerance. We present a photothermoelectric therapy (PTET) strategy based on triphenylphosphine-functionalized Cu3VS4 nanoparticles (CVS NPs) with high copper ionic mobility at room temperature. Under near-infrared laser irradiation, CVS NPs not only generate hyperthermia to ablate tumor cells but also catalytically yield superoxide radicals and induce endogenous NADH oxidation through the Seebeck effect. Notably, CVS NPs can accumulate inside mitochondria and deplete NADH, reducing ATP synthesis by competitively inhibiting the function of complex I, thereby down-regulating the expression of heat shock proteins to relieve tumor thermotolerance. Both in vitro and in vivo results show notable tumor suppression efficacy, indicating that the concept of integrating PTET and mitochondrial metabolism modulation is highly feasible and offers a translational promise for realizing precise and efficient cancer treatment. Triphenylphosphine-modified Cu3VS4 nanoparticles with copper ionic mobility are developed for photothermoelectric tumor therapy.
Science Advances 2023