Alcohol Drinking Without Meals Is Associated with Risk of Gastrointestinal Cancers, Including Early-Onset Cases
Menée à partir de données 2006-2021 de la "UK Biobank" portant sur 347 591 personnes, cette étude analyse l'association entre la consommation d'alcool sans nourriture et le risque de cancer gastro-intestinal (6 813 cas) en fonction de l'âge au diagnostic (avant ou après 55 ans)
Globally, gastrointestinal (GI) cancers account for about 27% of newly diagnosed cancer cases and 37% of cancer deaths.1 Intriguingly, there has been an upward trend in the incidence of several GI cancers (gastric noncardia, pancreatic, and colorectal cancer) among adults younger than 50 or 55 years over the past several decades. Alcohol drinking, a pervasive behavior across the globe and a causal risk factor for esophageal squamous cell carcinoma, liver cancer, and colorectal cancer, is also gaining recognition as a potential risk factor for gastric, pancreatic, and gallbladder cancers. Most studies have focused on the amount of alcohol, often highlighting dose-response relationship; there is scarce data exploring the effect of timing of drinking on GI cancer. Recently, skipping meals prior to drinking has been gaining popularity among young adults to save calories and avoid weight gain. However, the independent impact of such contemporary drinking patterns on risk of GI cancers, especially those of early-onset, has not been investigated.