Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma
Menée à partir d'échantillons sériques et d'échantillons fécaux prélevés sur un modèle murin et sur des patients atteints d'un carcinome hépatocellulaire, cette étude met en évidence l'intérêt d'une administration orale d'un mélange de probiotiques contenant la bactérie Bifidobacterium longum pour réduire le délai de récupération de la fonction hépatique après une hépatectomie
Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts and identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC patients with delayed recovery to mice similarly impacted recovery time post hepatectomy. However, oral gavage of B. longum improved liver function and repair in these mice. In a clinical trial of HCC patients, orally administering a probiotic bacteria cocktail containing B. longum reduced the rates of delayed recovery, shortened hospital stays, and improved overall 1-year survival. These benefits, attributed to diminished liver inflammation, reduced liver fibrosis, and hepatocyte proliferation, were associated with changes in key metabolic pathways, including 5-hydroxytryptamine, secondary bile acids, and short-chain fatty acids. Our findings propose that gut microbiota modulation can enhance LFR, thereby improving postoperative outcomes for HCC patients.
Cell Host & Microbe , article en libre accès, 2022