Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis
Menée à partir d'échantillons sériques prélevés sur 157 témoins et 26 patients présentant une colite induite par des inhibiteurs de point de contrôle immunitaire (ICI), cette étude met en évidence l'intérêt des auto-anticorps anti-intégrine alpha v bêta 6 pour le diagnostic, la classification et le suivi d'une colite liée aux ICI
Background : No specific biomarker for immune checkpoint inhibitor (ICI)-induced colitis has been established. Previously, we identified anti-integrin
αvβ6 autoantibodies in >90% of patients with ulcerative colitis (UC). Given that a subset of ICI-induced colitis is similar to UC, we aimed to clarify the relationship between such autoantibodies and ICI-induced colitis.
Methods
:
Serum anti-integrin αvβ6 autoantibody levels were compared between 26 patients with ICI-induced colitis and 157 controls. Endoscopic images of ICI-induced colitis were centrally reviewed. Characteristics of anti-integrin αvβ6 autoantibodies in the ICI-induced colitis patients were compared with those of UC patients.
Results
:
Anti-integrin αvβ6 autoantibodies were found in 8/26 (30.8%) patients with ICI-induced colitis and 3/157 (1.9%) controls (P
< 0.001). Patients with anti-integrin
αvβ6 autoantibodies had significantly more typical UC endoscopic features than those without the autoantibodies (P
< 0.001). Anti-integrin
αvβ6 autoantibodies in ICI-induced colitis patients were associated with grade
≥
3 colitis (P = 0.001) and steroid resistance (P = 0.005). Anti-integrin
αvβ6 autoantibody titers correlated with ICI-induced colitis disease activity. Anti-integrin αvβ6 autoantibodies of ICI-induced colitis exhibited similar characteristics to those of UC.
Conclusions
:
Anti-integrin αvβ6 autoantibodies may serve as potential biomarkers for the diagnosis, classification, risk management, and monitoring the disease activity, of ICI-induced colitis.
British Journal of Cancer , article en libre accès, 2024