Improving Noninvasive Colorectal Cancer Screening
Menée à partir d'échantillons fécaux collectés auprès de 20 176 participants asymptomatiques âgés de 40 ans ou plus, cette étude évalue, par rapport à un test FIT, la performance d'un test ADN multicible pour détecter des lésions précancéreuses de stade avancé ou un cancer colorectal
Noninvasive colorectal cancer screening commenced historically with the use of guaiac-based tests that require the addition of hydrogen peroxide to oxidize the presence of substances such as blood in stool. Large, randomized, controlled trials of these tests in a screened population showed the detection of earlier-stage cancers that could be curable, a reduction in mortality from colorectal cancer, and durability in the avoidance of colorectal cancer in persons who completed colonoscopy with polypectomy after a positive test.1 These benefits from guaiac-based screening were present despite the poor sensitivity of such tests, the requirement for diet alteration before test completion for . . (...)
New England Journal of Medicine , éditorial en libre accès, 2023