Neoadjuvant EGFR-TKI therapy in Non-Small cell lung cancer
Cette étude passe en revue les essais évaluant l'efficacité des traitements néoadjuvants par inhibiteurs de tyrosine kinase de l'EGFR en monothérapie ou en combinaison avec des chimiothérapies ou des immunothérapies chez les patients atteints d'un cancer du poumon non à petites cellules
Non-small cell lung cancer (NSCLC) stages I-III are predominantly treated with surgery and combination immunotherapy and chemotherapy. A majority of these studies excluded patients with EGFR and ALK mutations. There are several completed and ongoing trials evaluating neoadjuvant treatment with EGFR-TKI monotherapy, combination therapy with chemotherapy, and combination therapy with immunotherapy. Here, we review completed clinical trials and discuss current ongoing trials’ potential benefits, challenges, and future directions in the field.