History of infertility and risk of colorectal cancer
Menée à l'aide de données de la "Women’s Health Initiative (WHI)", cette étude analyse l'association entre une infertilité et le risque de cancer colorectal après la ménopause (2 680 cas)
Background: There has been limited prior research on the association between infertility and risk of colorectal cancer. Methods: Data from postmenopausal women in Women’s Health Initiative (WHI) were used to estimate the association between self-reported infertility (twelve months of trying to get pregnant without achieving a pregnancy) with risk of colorectal cancer using Cox proportional hazard models. Results: No association was observed between infertility and risk of postmenopausal colorectal cancer (RR: 0.97, 95% CI: 0.87-1.08), invasive colorectal cancer (RR:0.99, 95% CI: 0.88-1.10), or colorectal cancer mortality (RR: 0.89, 95% CI: 0.71-1.12). Conclusions: Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses. Impact: Infertility may not be associated with colorectal cancer risk.