Primary Cytoreduction and Survival for Patients With Less-Common Epithelial Ovarian Cancer
Menée à l'aide de données portant sur 15 744 patientes atteintes d'un carcinome épithélial de l'ovaire de stade III, cette étude analyse la survie en fonction du volume tumoral résiduel après une chirurgie cytoréductive primaire, par type histologique
For advanced stage ovarian cancer, surgery to perform maximal tumor cytoreduction has been the mainstay of initial therapy. The extent of residual disease at the completion of surgery is highly prognostic, with lower-volume residual disease associated with improved survival. Prior studies examining the association between cytoreductive effort and survival have included mainly high-grade and serous ovarian tumors, the most common histologic subtype of ovarian cancer. The prognostic significance of cytoreductive status in less-common histologic types has been relatively understudied. Given the distinct clinical and biological differences across histologic subtypes in epithelial ovarian cancer data derived mainly from common high-grade serous tumors may not apply to less-common histologic types. The objective of this study was to examine the association between primary cytoreduction status and survival for patients with less-common, advanced-stage epithelial ovarian carcinoma.