New Insights in Endometriosis Subtypes and Ovarian Cancer Risk
Menée à l'aide de données américaines portant sur des témoins et 78 893 femmes atteintes d'endométriose, cette étude analyse l'association entre cette maladie et le risque de cancer de l'ovaire, par sous-type
In 2024, an estimated 19 680 new ovarian cancers and 12 740 ovarian cancer–related deaths will occur in the US. Early detection continues to be elusive and screening strategies inadequate, even in women at high risk. Women continue to be diagnosed with advanced-stage disease, which portends a poor prognosis despite improved outcomes in women treated with a poly(adenosine diphosphate-ribose) polymerase inhibitor for maintenance therapy, particularly those with germline or somatic BRCA1 or BRCA2 sequence variations.Multiple risk factors have been associated with epithelial ovarian cancer, including age, early menarche or late menopause, nulliparity, family history of breast or ovarian cancer, and BRCA1 and BRCA2 sequence variations. More recently, additional genetic variants in the homologous recombinant pathway, including BRIP1, RAD51C, and RAD51D, have been associated with an increased risk of ovarian cancer.
JAMA , éditorial en libre accès, 2023