Comparison of Survival and Complications Between Minimally Invasive and Open Staging Surgeries in Non-Endometrioid Endometrial Cancer
Menée à partir de données 2004-2017 portant sur 91 patientes atteintes d'un cancer de l'endomètre non endométrioïde, cette étude analyse la survie et les complications en fonction du type de chirurgie (chirurgie mini-invasive ou par voie ouverte) puis identifie des facteurs pronostiques associés
Objective: This study aimed to compare survival and complications between minimally invasive surgery and open surgery and evaluate related risk factors in patients with non-endometrioid endometrial cancer. Methods: Clinicopathologic characteristics; survival outcomes; complications; and prognostic factors associated with progression-free survival and overall survival were compared among patients with non-endometrioid endometrial cancer who underwent primary staging surgery using laparoscopic, robotic, or open abdominal surgery (2004–2017). Results: In total, 91 patients were included: 41 and 50 underwent minimally invasive surgery and open surgery, respectively. The minimally invasive surgery and open surgery groups showed similar progression-free survival (5-year progression-free survival rate, 58.7% vs. 58.5%; P=0.925) and overall survival (5-year overall survival rate, 73.6% vs. 80.3%; P=0.834). Intraoperative (7.2% vs. 6.0%; P=0.111) and postoperative surgical complications (14.6% vs. 26.0%; P=0.165) were similar between the groups. However, blood loss was lower (mean, 305.1 vs. 561.2 ml, P<0.001) and hospital stay was shorter (mean, 8.2 vs. 15.4 days, P<0.001) in the minimally invasive surgery group. Using multivariate analysis, lymphovascular space invasion was identified as poor prognostic factor for progression-free survival (adjusted hazard ratio [HR], 3.054; 95% confidence interval [CI], 1.521–6.132; P=0.002) and overall survival (adjusted HR, 3.918; 95% CI, 1.455–10.551; P=0.007), whereas age 60 years was poor prognostic factor for only overall survival (adjusted HR, 5.0953; 95% CI, 1.660–15.378; P=0.004). Conclusions: Surgical outcomes did not differ between the minimally invasive and open surgery group in patients with non-endometrioid endometrial cancer. Lymphovascular space invasion was a significant survival factor in this context.