Dietary Flavonoids and Lung Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis of Observational Studies
A partir d'une revue systématique de la littérature publiée jusqu'en avril 2023 (20 études), cette méta-analyse évalue l'association entre une consommation de polyphénols et le risque de cancer du poumon
Individual observational studies examining the association between polyphenols and the risk of lung cancer have reported mixed findings. Therefore, we performed a systematic review and meta-analysis to determine the pooled effects between polyphenol intake and lung cancer risk. A systematic search was performed on PubMed, Scopus, and Web of Science databases in April 2023. Random-effect models were used to estimate odd ratios (OR) and 95% confidence intervals (95% CI). In total, 20 studies were included in the systematic review. The pooled analyses indicated that a higher intake of flavonoids (OR = 0.81; 95% CI: 0.67,0.98; p?=?0.03) and isoflavone (OR = 0.82; 95% CI: 0.74,0.92; p?<?0.001) were associated with lower odds of lung cancer. In addition, the ingestion of anthocyanidin (OR = 0.80; 95% CI: 0.65,0.98; p?=?0.04), kaempferol (OR = 0.78; 95% CI: 0.64,0.96; p?=?0.02), quercetin (OR = 0.66; 95% CI: 0.48,0.91; p?=?0.01) and flavanones (OR = 0.71; 95% CI: 0.59,0.85; p?<?0.001) reduced the likelihood of developing lung cancer. Overall, our findings suggest that flavonoids, isoflavones, anthocyanidin, kaempferol, quercetin, and flavanones may protect against lung cancer.