Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report
Menée en Asie auprès de 4 544 témoins et 998 patientes atteintes d'un adénocarcinome pulmonaire et n'ayant jamais fumé, cette étude analyse l'association entre un score de risque polygénique et le risque de développer la maladie en fonction du statut mutationnel EGFR
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10-3). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer?s mutation status, which may have important public health and clinical implications.