A Comprehensive Systematic Review and Meta-analysis of the Role of Prostate-specific Membrane Antigen Positron Emission Tomography for Prostate Cancer Diagnosis and Primary Staging before Definitive Treatment
A partir d'une revue systématique de la littérature (111 études, 20 182 participants), cette méta-analyse examine le rôle, dans le diagnostic du cancer prostatique et la stadification de la maladie avant le traitement définitif, de la tomographie par émission de positons ciblant l'antigène de la membrane spécifique de la prostate
Our study corroborates the role of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) as an important tool in the diagnosis and staging of prostate cancer (PCa), offering good accuracy in detecting clinically significant PCa and metastatic disease, especially when combined with magnetic resonance imaging. Its effectiveness is notably high for high-risk patients, helping tailor treatment strategies with precise staging information. The ability of PSMA PET to detect lymph node and distant metastases underscores its importance in primary staging, guiding clinicians toward more individualized and effective treatment decisions. These findings support the integration of PSMA PET into routine PCa management, improving diagnostic precision and staging accuracy.
European Urology , article en libre accès, 2025