Fighting Sarcomas at the Root: The Role of Mesenchymal Stem Cells in Sarcomagenesis
Cet article examine le rôle des cellules souches mésenchymateuses dans la sarcomagenèse
Mesenchymal stem cells (MSCs) are multipotent progenitor cells niching in various tissues, which contribute to organ development and regeneration and play a major role in oncogenesis. In the era of improved understanding of cancer biology and targeted therapies, oncogenic events represent potential targets for novel treatment strategies. This review aimed to describe the main physiological and pathophysiological roles of MSCs related to mesenchymal tissues and their deriving sarcoma. The ability of MSCs to differentiate into osteogenic, chondrogenic and adipogenic lineages leads to skeletal growth, maintenance, and repair. Within the tumor microenvironment, MSCs can interact with cancer cells, influencing tumor growth, immune response modulation and metastatic potential. Understanding the link between MSCs and the cell of origin in sarcomas could provide new insights into disease mechanisms and uncover new therapeutic targets.
European Journal of Cancer , résumé, 2025