Characterizing the Killer Colorectal Carcinomas
A partir d'échantillons tumoraux prélevés sur 1 134 patients atteints d'un cancer colorectal métastatique, cette étude dresse le catalogue des anomalies génomiques, notamment en fonction de la localisation (droite ou gauche) de la tumeur primitive
In this issue of Cancer Cell, Yaeger et al. report mutations, copy number variations, and selected rearrangements from a large series of metastatic colorectal carcinomas and primaries that produced metastases. The results provide important insights into differences in anatomical site of origin, age at onset, etiologic factors, and therapeutic responses.
Cancer Cell 2018