Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues
Menée à l'aide de modèles murins, cette étude met en évidence des mécanismes de nature métabolique par lesquels la protéine PKM1 favorise la prolifération des cellules cancéreuses
Altered glucose metabolism is common in cancer. In this issue of Cancer Cell, Morita et al. report new mouse models that express specific isoforms of pyruvate kinase to study glycolysis in tumors. They report several unanticipated findings that challenge current ideas in cancer metabolism.
Cancer Cell 2018