Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment
Cet article passe en revue les travaux récents sur les cellules souches cancéreuses et le micro-environnement tumoral dans les cancers du système nerveux
Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
http://linkinghub.elsevier.com/retrieve/pii/S1934590911001780 2011