Skin-Cancer Chemoprevention in Transplant Recipients
Mené sur 158 patients ayant reçu une greffe d'organe, cet essai randomisé de phase III analyse l'intérêt du nicotinamide (vitamine B3) dispensé par voie orale pour prévenir le risque de cancer de la peau non mélanome (carcinome basocellulaire et épidermoïde)
Keratinocyte carcinomas include squamous-cell carcinoma of the skin and basal-cell carcinoma and are the predominant forms of nonmelanoma skin cancer. Keratinocyte carcinomas are the most common cancer in humans, with an annual incidence greater than all other cancers combined.1,2 Whereas the vast majority of basal-cell and squamous-cell carcinomas are cured with local destruction or surgical excision, treatment of keratinocyte carcinomas can lead to considerable morbidity and health care–related economic burden. Furthermore, a subgroup of patients with nonmelanoma skin cancers have poor outcomes, including recurrence, metastases, and death. Owing to the sheer number of keratinocyte carcinomas that are diagnosed each year (....)