Take a pill for no more polyps: is it that simple?
Mené sur 709 participants atteints d'une néoplasie colorectale sporadique détectée par coloscopie, cet essai randomisé évalue l'intérêt de l'acide icosapentaénoïque et de l'aspirine, utilisés seuls ou en combinaison, pour prévenir le développement d'un adénome colorectal
Colonoscopy is regarded as the gold standard for detection of colorectal cancer and its precursors, colorectal adenomas and sessile serrated lesions. This procedure should be able to prevent colorectal cancer by detecting and removing those precursor lesions. After adenoma or sessile serrated lesion resection, individuals are considered to be at high risk of developing metachronous lesions and colorectal cancer, and are therefore advised to undergo surveillance colonoscopy. Despite these preventive measures, post-colonoscopy colorectal cancers (PCCRCs) occur at a frequency of up to 8·6%.Chemoprevention has the potential to reduce the occurrence of metachronous adenomas and colorectal cancers. Such an anticolorectal cancer effect is known for aspirin. Furthermore, evidence suggests that fish oils might be useful in the prevention of colorectal cancer, although the mechanism of antineoplastic activity is not fully understood. The naturally occurring omega-3 polyunsaturated fatty acid C20:5n3 eicosapentaenoic acid (EPA) has clinical proof of concept as a polyp-reducing agent from a randomised controlled trial (RCT) in patients with familial adenomatous polyposis malignant. (...)
The Lancet 2018