Risk-reducing surgery in BRCA carriers: do we need more evidence?
Ce dossier présente 2 études analysant l'effet d'une chirurgie prophylactique (salpingo-ovariectomie bilatérale et/ou mastectomie) sur la santé à long terme ou la survie des patientes présentant une mutation des gènes BRCA et des antécédents personnels de cancer du sein
Two studies in The Lancet Oncology address the role of risk-reducing salpingo-oophorectomy and mastectomy to reduce the risk of ovarian and breast cancers in BRCA pathogenic variant carriers. Risk-reducing surgery is not a new concept. In a 1958 editorial, Culiner1 addressed the controversial practice of oophorectomy at the time of hysterectomy to reduce ovarian cancer risk, concluding that “the most favorable results will probably be achieved by pondering the individual merits of the procedure,” and predicting personalised medicine's role today, nearly 70 years ago.
The Lancet Oncology , commentaire, 2025