Exercise and Physical Medicine Interventions for Managing Chemotherapy-Induced Peripheral Neuropathy
Mené en Allemagne sur 158 patients (durée de suivi : au moins 5 ans ; âge moyen : 49,1 ans ; 59 % d'hommes), cet essai randomisé multicentrique évalue l'effet d'un entraînement neuromusculaire sur la survenue d'une neuropathie périphérique induite par la chimiothérapie
Chemotherapy-induced peripheral neuropathy (CIPN) is a frustrating and distressing complication of many chemotherapy drugs. In addition to bothersome symptoms, such as numbness and tingling, CIPN can affect daily living and socio-occupational function, cause balance disequilibrium and falls, and limit the amount of chemotherapy that can be administered, contributing to worse oncological outcomes. Current evidence-based approaches for treatment of established CIPN are limited; duloxetine has shown modest efficacy in improving painful neuropathy (average improvement in pain of 1 point vs 0.3 points for placebo on a 10-point scale). Given the lack of effective treatment, there is growing recognition of the importance of primary prevention of CIPN in the oncology community. The association of obesity and lower physical activity with CIPN and recognition of exercise-based interventions in improving general health, inflammation, and neuromodulation have been followed by increasing interest in evaluating exercise-based interventions (exercise oncology) in managing CIPN.