Prognostic Immune Markers in Non-Small Cell Lung Cancer
Cet article passe en revue les travaux récents sur les marqueurs immunitaires pour le pronostic des cancers du poumon non à petites cellules
Tumor-associated immune responses have polarized effects in regulating tumor growth. While a clear association has been shown between the tumor immune response and clinical outcome in colorectal and ovarian cancers, the role of immune markers for stratifying prognosis in non-small cell lung cancer (NSCLC) is less defined. Herein we review the prognostic significance of published immune markers in the tumor microenvironment as well as peripheral blood of NSCLC patients. To identify prognostic immune genes, we reviewed all published gene profiling studies in NSCLC and delineated the significance of immune genes by performing subanalysis on the microarray database of the NIH Director's Challenge study. This first comprehensive review of prognostic immune markers provides a foundation for further investigating immune responses in NSCLC.
Clinical Cancer Research , résumé, 2011