Tobacco Smoking and Cutaneous Squamous Cell Carcinoma: A 16 -Year Longitudinal Population-Based Study
Menée en population australienne (1 287 participants âgés de 25 à 75 ans), cette étude longitudinale évalue l’association entre le tabagisme et le risque de carcinome spinocellulaire
Background: Although tobacco smoking is commonly cited as a risk factor for cutaneous squamous cell carcinoma (SCC), the evidence from previous clinical and case-control studies is conflicting. We therefore aimed to prospectively examine the role of tobacco smoking in the development of SCC of the skin in a population-based study. Methods: Study participants were 1287 adults aged 25 to 75 years in 1992, randomly selected from the Nambour community, with no previous history of SCC. Standard skin pigment and sun-sensitivity profiles were obtained at baseline. Detailed prospective information on sun exposure, smoking and skin cancer occurrence (histologically-confirmed) was collected over a 16-year period, 1992-2007. Results: Of 1287 participants, 43% were male, and average age was 48 years. A total of 188 first cutaneous SCCs were identified during the study period. After adjustment for other known risk factors, neither former nor current smokers were at raised risk of SCC: RR 1.1, 95%CI 0.8, 1.5 and RR 1.1, 95%CI 0.7, 1.5, respectively, compared with lifelong non-smokers, nor were there any dose-response relationships with amount smoked or duration of smoking and risk of SCC. Conclusions: In this Australian follow-up study tobacco smoking did not increase the risk of SCC of the skin. Impact: These prospective adjusted data provide strong evidence which suggests that smoking should not be on the list of tobacco-related cancers.
http://cebp.aacrjournals.org/content/early/2011/06/16/1055-9965.EPI-11-0150.abstract