Pro-senescence therapy for cancer treatment
Cet article passe en revue les perspectives offertes par des agents thérapeutiques favorisant la sénescence cellulaire dans le traitement des cancers
Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.