Exercise for Prostate Cancer—Worthy Goals but Suboptimal Trial Designs
Mené sur 53 patients atteints d'un cancer de la prostate (âge médian : 61 ans), cet essai de phase I détermine la faisabilité et l'effet, sur la prolifération des cellules cancéreuses, de différentes intensités d'exercices physiques avant un traitement chirurgical
Physical activity is increasingly recognized as a modifiable factor that may influence cancer outcomes. In 2022, an American Society of Clinical Oncology Expert Panel issued a clinical practice guideline on exercise during cancer treatment. Based on a rigorous systematic review process, the panel concluded that exercise interventions during cancer treatment reduced fatigue, enhanced quality of life, and improved physical function. However, evidence was insufficient in the American Society of Clinical Oncology report to determine whether exercise would improve cancer outcomes. The American Cancer Society, the World Cancer Research Fund, and the American College of Sports Medicine have all published guidelines or position statements supporting physical activity for patients with cancer and the potential relationship with improved outcomes. Specifically related to prostate cancer, the 2022 American Cancer Society guidelines report noted that consistent evidence exists supporting associations of physical activity with lower total and prostate cancer–specific mortality. Similarly, the 2019 American College of Sports Medicine report noted that physical activity was associated with a 33% lower risk of cancer-specific mortality in patients with prostate cancer.