Expanding early detection of anal cancer to improve survival
Menée aux Etats-Unis à partir de données portant sur 21 824 patients atteints d'un cancer invasif de l'anus diagnostiqué entre 2001 et 2019, cette étude de cohorte rétrospective analyse la survie en fonction du sexe et de la présence d'une infection par le VIH (2 662 cas)
As the emergence of antiretroviral therapy (ART) has improved survival in people with HIV, the prevalence of age-related diseases, such as cancer, has increased. Specifically, the incidence of anal cancer has escalated in people with HIV with oncogenic HPV, 1 , 2 , 3 , 4 leading to a growing population of people with HIV diagnosed with anal cancer. Consequently, questions have arisen regarding whether controlling HIV with ART leads to an increased risk of overall or anal-cancer specific mortality, and whether screening for anal cancer can detect disease at earlier stages to improve prognoses.