Bulletin n°112
Biologie
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Aberrations chromosomiques (3)
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Menée sur 54 échantillons tumoraux prélevés sur des patients atteints d'un carcinome à cellules claires du rein, cette étude identifie des anomalies génomiques associées à deux sous-types de ce cancer
Integrative genomic analyses of sporadic clear cell Renal Cell Carcinoma define disease subtypes and potential new therapeutic targets
Cancer Research
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Menée sur des échantillons tumoraux prélevés sur 186 patients atteints d'une leucémie lymphocytaire chronique, cette étude identifie de fréquentes mutations du gène NOTCH1 en association avec une trisomie 12
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Dossier
Ces deux études présentent des analyses complémentaires de mécanismes évolutifs impliqués dans l'apparition d'anomalies de copies de gènes dans les cellules cancéreuses
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Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19
Cell
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Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus
Cell
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Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
Science
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Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient
Cell
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Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
Nature
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MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
Cancer Cell
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Combinatorial Haplo-Deficient Tumor Suppression in 7q-Deficient Myelodysplastic Syndrome and Acute Myeloid Leukemia
Cancer Cell
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Identification of RASAL1 as a Major Tumor Suppressor Gene in Thyroid Cancer
Journal of the National Cancer Institute
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RASAL1 in Thyroid Cancer: Wisdom From an Old Foe
Journal of the National Cancer Institute
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New Insights into von Hippel-Lindau Function Highlighted by Investigation of the Trichloroethylene-Induced p.P81S Hotspot Mutation
Journal of the National Cancer Institute
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Pleiotropic Effects of the Trichloroethylene-Associated P81S VHL Mutation on Metabolism, Apoptosis, and ATM-Mediated DNA Damage Response
Journal of the National Cancer Institute
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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Nature
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IDH mutation impairs histone demethylation and results in a block to cell differentiation
Nature
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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Nature
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Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1
Cancer Cell
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Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Cell
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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Cell
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DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes
Nature Biotechnology
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High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
Nature Biotechnology
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Oncogènes et suppresseurs de tumeurs (7)
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Cette étude montre que l'expression anormale des histones déacétylases réduit au silence 3 micro-ARNs suppresseurs de tumeurs dans la leucémie lymphocytaire chronique
Histone deacetylases mediate the silencing of miR-15a, miR-16 and miR-29b in chronic lymphocytic leukemia
Blood
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Cet article présente un modèle théorique qui, basé sur la structure de la niche des cellules souches, vise à rendre compte du vieillissement des organes et de la susceptibilité au cancer
Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche
Proceedings of the National Academy of Sciences
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Cet article passe en revue les travaux récents sur la biologie moléculaire des tumeurs stromales gastro-intestinales
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Cet article passe en revue les travaux récents sur le rôle d'un métabolisme anormal de la choline dans la transformation maligne
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Menée in vitro, cette étude identifie une voie de signalisation qui, en cas de métabolisme mitochondrial défaillant dans les cellules tumorales, permet d'assurer leur croissance
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Nature
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Menée à l'aide d'un modèle murin de leucémie myélogène chronique, cette étude met en évidence le rôle joué par une cytokine pro-inflammatoire, l'interleukine 6, dans l'environnement tumoral et les cellules souches leucémiques
IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development
Cancer Cell
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Cet article passe en revue les travaux récents sur le rôle du gène suppresseur de tumeur BRCA1 dans la régulation de la transcription, notamment dans le cancer du sein triple négatif
BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype
Cancer and Metastasis Reviews
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Progression et métastases (4)
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Cette étude montre que, dans des cellules tumorales d'un carcinome canalaire du pancréas, un faible niveau d'expression du facteur de transcription GLI1 est associé à un phénotype hautement métastatique
GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells
Cancer Research
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Cet article passe en revue les travaux récents sur le rôle des fibroblastes associés aux tumeurs dans la progression et le processus métastatique du cancer
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
Cancer and Metastasis Reviews
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Menée in vitro et in vivo, cette étude met en évidence le rôle joué par la kinase PAK1 dans la progression du cancer colorectal
P-21 Activated Kinase 1 Knockdown Inhibits β-Catenin Signalling and Blocks Colorectal Cancer Growth
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Dossier
Menée in vitro et in vivo, cette étude identifie un mécanisme de signalisation entre cellules cancéreuses et thrombocytes induisant une transition épithélio-mésenchymateuse et favorisant le processus métastatique
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Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization
Nature Cell Biology
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Genetic Ancestry May Influence the Evolutionary Trajectory of Cancers
Cancer Cell
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Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers
Cancer Cell
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Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
Cell
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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
Cell
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Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Cell
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The Making of a PreCancer Atlas: Promises, Challenges, and Opportunities
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Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma
Cell
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Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus
Nature
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p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
Cancer Cell
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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Nature
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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
Nature
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The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis
Cancer Cell
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PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
Cancer Cell
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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
Nature
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A New Lnc in Metastasis: Long Noncoding RNA Mediates the ProMetastatic Functions of TGF-β
Cancer Cell
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A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma
Cancer Cell
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Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response
Cancer Cell
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Regional Activation of the Cancer Genome by Long-Range Epigenetic Remodeling
Cancer Cell
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Role of aerobic glycolysis in genetically engineered mouse models of cancer
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Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
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EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance
Cell
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Tumor-Induced Osteoclast miRNA Changes as Regulators and Biomarkers of Osteolytic Bone Metastasis
Cancer Cell
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Cancer-Associated Osteoclast Differentiation Takes a Good Look in the miR(NA)ror
Cancer Cell
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A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis
Cancer Cell
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Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies
Cell
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Understanding Metastasis in Pancreatic Cancer: A Call for New Clinical Approaches
Cell
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Deconvoluting the context-dependent role for autophagy in cancer
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Autophagy in tumorigenesis and cancer therapy: Dr Jekyll or Mr Hyde?
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Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
Cancer Cell
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Silencing the Killers: Paracrine Immune Suppression in Pancreatic Cancer
Cancer Cell
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