Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies
A partir d'une revue systématique de la littérature publiée jusqu'en août 2011 (16 études prospectives), cette méta-analyse évalue l'association entre la consommation de fibres alimentaires et le risque de cancer du sein
Background: Evidence from case–control studies suggest that dietary fiber may be inversely related to breast cancer risk, but it is unclear if this is supported by prospective data. We conducted a systematic review and meta-analysis of the evidence from prospective studies.Methods: PubMed was searched for prospective studies of fiber intake and breast cancer risk until 31st August 2011. Random effects models were used to estimate summary relative risks (RRs).Results: Sixteen prospective studies were included. The summary RR for the highest versus the lowest intake was 0.93 [95% confidence interval (CI) 0.89–0.98, I2 = 0%] for dietary fiber, 0.95 (95% CI 0.86–1.06, I2 = 4%) for fruit fiber, 0.99 (95% CI 0.92–1.07, I2 = 1%) for vegetable fiber, 0.96 (95% CI 0.90–1.02, I2 = 5%) for cereal fiber, 0.91 (95% CI 0.84–0.99, I2 = 7%) for soluble fiber and 0.95 (95% CI 0.89–1.02, I2 = 0%) for insoluble fiber. The summary RR per 10 g/day of dietary fiber was 0.95 (95% CI 0.91–0.98, I2 = 0%, Pheterogeneity = 0.82). In stratified analyses, the inverse association was only observed among studies with a large range (≥13 g/day) or high level of intake (≥25 g/day).Conclusion: In this meta-analysis of prospective studies, there was an inverse association between dietary fiber intake and breast cancer risk.