Cutaneous toxicities of RAF inhibitors
Cet article passe en revue les travaux récents sur les toxicités cutanées associées aux inhibiteurs de BRAF pour le traitement d'un mélanome métastatique
The RAF inhibitors vemurafenib and dabrafenib are emerging as the standard of care for Val600BRAF-mutant metastatic melanoma. These drugs have shown clinical benefit over the standard care (dacarbazine); however, they are associated with frequent cutaneous adverse events, which can be concerning to the patient and their physician. Herein, we review the range of cutaneous disorders that seem to be induced by RAF inhibitors, including cutaneous squamous-cell carcinoma, hyperkeratotic lesions, Grover's disease, keratosis pilaris-like reactions, and photosensitivity. These disorders often affect patients' quality of life; therefore, dermatological assessment and timely management is essential to ensure that patients continue to use RAF inhibitors.