Dietary Fiber Intake Reduces Risk for Gastric Cancer: a Meta-Analysis
A partir d'une revue de la littérature publiée jusqu'en octobre 2012 (21 articles, 580 064 participants), cette méta-analyse montre que la consommation de fibres d'origine alimentaire réduit le risque de cancer de l'estomac
The association between dietary fiber intake and gastric cancer risk has been investigated by many studies, with inconclusive results. We conducted a meta-analysis of case-control and cohort studies to analyze this association. Relevant studies were identified by searching PubMed and Embase through October 2012. We analyzed 21 articles, which included 580,064 subjects. Random effects models were used to estimate summary relative risks. Dose-response, subgroup, sensitivity, meta-regression, and publication bias analyses were performed. The summary odds ratios of gastric cancer for the highest, compared with the lowest, dietary fiber intake was 0.58 (95% confidence interval, 0.49–0.67) with significant heterogeneity among studies P<.001, I2 = 62.2%). Stratified analysis for study design, geographic area, source and type of fiber, Lauren’s classification, publication year, sample size, and quality score of study yielded consistent results. Dose-response analysis associated a 10 g/d increment in fiber intake with a significant (44%) reduction in gastric cancer risk. Sensitivity analysis restricted to studies with control for conventional risk factors produced similar results, and omission of any single study had little effect on the combined risk estimate. In a meta-analysis, we show that dietary fiber intake is inversely associated with gastric cancer risk; the effect is probably independent of conventional risk factors. The direction of the protective association of dietary fiber was consistent among all studies, but the absolute magnitude is less certain, because of heterogeneity among the studies. Further studies are therefore required to establish this association.
http://linkinghub.elsevier.com/retrieve/pii/S0016508513004927?showall=true