6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-κB Signaling
Menée sur des cellules cancéreuses humaines ou murines du pancréas et à l'aide de xénogreffes, cette étude montre que le 6-shogaol, un composé phénolique extrait du gingembre séché, peut inhiber la croissance tumorale via l'inhibition de la signalisation STAT3 et NF-κB
Despite much recent progress, prostate cancer (PCa) continues to represent a major cause of cancer-related mortality and morbidity in men. PCa is the most common non-skin neoplasm and second leading cause of death in men. 6-Shogaol (6-SHO), a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been shown to possess anti-inflammatory and anticancer activity. In the present study, the effect of 6-SHO on the growth of PCa cells was investigated. 6-SHO effectively reduced survival and induced apoptosis of cultured human (LNCaP, DU145 and PC3) and mouse (HMVP2) PCa cells. Mechanistic studies revealed that 6-SHO reduced constitutive and IL-6 induced STAT3 activation and inhibited both constitutive and TNF-α induced NF-κB activity in these cells. In addition, 6-SHO decreased the level of several STAT3 and NF-κB regulated target genes at the protein level, including cyclin D1, survivin and cMyc and modulated mRNA levels of chemokine, cytokine, cell cycle and apoptosis regulatory genes (IL-7, CCL5, BAX, BCL2, p21 and p27). 6-SHO was more effective than two other compounds found in ginger, 6-gingerol and 6-paradol at reducing survival of PCa cells and reducing STAT3 and NF-κB signaling. 6-SHO also showed significant tumor growth inhibitory activity in an allograft model using HMVP2 cells. Overall, the current results suggest that 6-SHO may have potential as a chemopreventive and/or therapeutic agent for PCa and that further study of this compound is warranted.