The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
Cet article passe en revue les travaux récents sur le rôle de processus systémiques complexes dans la progression d'un cancer
Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
Nature Cell Biology , résumé, 2013