Hsp70 in cancer: back to the future
Cet article passe en revue les perspectives thérapeutiques offertes par les connaissances récentes sur le rôle de la protéine de choc thermique Hsp70 dans le développement et la progression d'une tumeur
Mechanistic studies from cell culture and animal models have revealed critical roles for the heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of Hsp70 on cancer have not been related to its chaperone activity, but rather to its role(s) in regulating cell signaling. A major factor that directs Hsp70 signaling activity appears to be the co-chaperone Bag3. Here, we review these recent breakthroughs, and how these discoveries drive drug development efforts.