SUMO and the robustness of cancer
Cet article passe en revue les travaux récents sur le rôle des protéines SUMO, associées à un mécanisme de modification post-traductionnelle, dans la tumorigenèse
Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.