• Biologie

  • Progression et métastases

Dormant tumour cells, their niches and the influence of immunity

Cet article passe en revue les travaux récents sur les mécanismes par lesquels le système immunitaire favorise l'émergence d'une niche métastatique en induisant le "réveil" des cellules tumorales dormantes

Despite increased focus on the clinical relevance of dormant metastatic disease, our understanding of dormant niches, mechanisms underlying emergence from dormancy, and the immune system’s role in this phenomenon, remains in its infancy. Here, we discuss key work that has shaped our current understanding of these topics. Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease.

Nature Cell Biology

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