Irreversible electroporation for liver cancer ablation: A meta analysis
A partir d'une revue systématique de la littérature publiée entre janvier 2010 et juillet 2021 (26 études, 807 patients), cette méta-analyse évalue l'efficacité et la toxicité d'une ablation par électroporation irréversible dans le traitement du cancer du foie, en particulier du point de vue des dommages causés au tractus gastro-intestinal, aux voies biliaires et aux vaisseaux vitaux
Objective: To evaluate the efficacy and safety of IRE in the treatment of hepatic malignant tumors, especially the damage to the gastrointestinal tract, bile ducts, and vital vessels. Methods: The relevant literatures published from January 1, 2010 to July 1, 2021 were searched from PubMed and Embase databases. The following keywords were applied: “irreversible electroporation”, “IRE”, “unresectable Hepa* cancer”, “ablation” and “ablation therapy". Results: Twenty-six studies were identified covering 807 participants and 1115 lesions. The complete ablation rate of liver cancer by IRE was 86% (95% CI: 81%–90%). The incidence of IRE-related complications was 23% (95% CI: 17%–28%), but most of them were minor, major complications such as biliary fistula, intestinal fistula and massive hemorrhage were rare. Conclusion: Meta-analysis showed that IRE ablation is safe and effective for liver cancer treatment. Bile duct, intestine and blood vessels adjacent to the tumors are rarely damaged by IRE ablation.