Bulletin n°115
Traitements
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Combinaison de traitements localisés et systémiques (4)
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A partir d'un essai de phase III incluant 246 patients (âge supérieur à 70 ans) atteints d'un cancer avancé du poumon et inopérables, cette étude analyse l'efficacité et la toxicité d'une chimioradiothérapie concomittante à base de cisplatine-étoposide et combinée ou non à une chimiothérapie de consolidation par docétaxel
Updated survival and outcomes for older adults with inoperable stage III non-small-cell lung cancer treated with cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel: analysis of a phase III trial from the Hoosier Oncology Group (HOG) and US Oncology
Annals of Oncology
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Mené sur 50 patients atteints d'un sarcome des tissus mous et présentant un risque élevé de récidive (33 hommes, 17 femmes ; âge médian : 50,1 ans ; durée médiane de suivi : 30,5 mois), cet essai de phase II évalue la faisabilité, l'efficacité et la toxicité d'un protocole thérapeutique combinant une chimiothérapie néo-adjuvante de type EIA (étoposide-ifosfamide-doxorubicine-pegfilgrastime), une résection chirurgicale et une radiothérapie
A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma
BMC Cancer
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Mené sur 508 patients atteints d'un cancer nasopharyngé de stade III / IV (durée médiane de suivi : 37,8 mois), cet essai multicentrique randomisé de phase III évalue l'intérêt d'ajouter une chimiothérapie adjuvante à une chimioradiothérapie concomittante
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial
The Lancet Oncology
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Menée in vitro, cette étude montre que l'inhibition de l'expression des kinases Aurora augmente la sensibilité des cellules de glioblastome au témozolomide et aux rayonnements ionisants
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells
Journal of Cancer Research and Clinical Oncology
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Traitements localisés : applications cliniques (4)
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Menée sur 57 patients atteints d'un cancer du poumon non à petites cellules de stade III A / III B et inopérables, cette étude rétrospective évalue l'efficacité d'une protonthérapie seule, non combinée à une chimiothérapie concomittante
Results of Proton Beam Therapy without Concurrent Chemotherapy for Patients with Unresectable Stage III Non-small Cell Lung Cancer
Journal of Thoracic Oncology
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A partir d'une revue de la littérature publiée entre 1980 et 2011, cet article analyse l'impact à long terme d'une prostatectomie radicale sur le risque de récidive d'un cancer de la prostate ainsi que sur les résultats fonctionnels, et évalue les facteurs associés
A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes
European Urology
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Dossier
Mené sur 153 patients atteints d'un cancer de la prostate (durée médiane de suivi : 50,5 mois), cet essai randomisé multicentrique compare l'efficacité et la toxicité d'une radiothérapie conventionnelle et d'une radiothérapie hypofractionnée avec modulation d'intensité
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Practical Guide to the Use of AI-Enabled Analytics in Research
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Practical Guide to Artificial Intelligence, Chatbots, and Large Language Models in Conducting and Reporting Research
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Practical Guide to Patient-Generated Data Sources
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Practical Guide to Image-Based Big Data Research
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Best Practices for Big Data Sources and Methods in Surgery
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Practical Guide to Multiomics Big Data Sources
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Practical Guide to Clinical Big Data Sources
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Practical Guide to Remote Patient Monitoring in Surgical Patients
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Practical Guide to Administrative and Billing Big Data Sources
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Practical Guide to Use of Simulation and Video Data
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Completion axillary lymph node dissection for the identification of pN2-3 status as an indication for adjuvant CDK4/6 inhibitor treatment: a post-hoc analysis of the randomised, phase 3 SENOMAC trial
The Lancet Oncology
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Time to abandon axillary lymph node dissection in early-stage breast cancer
The Lancet Oncology
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High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3 Randomized Clinical Trial
Journal of Clinical Oncology
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Promises and Challenges of Dietary Intervention in Patients With Prostate Cancer: Lessons Learned From the CAPFISH-3 Trial
Journal of Clinical Oncology
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The Death D-Fying Vitamin D3 for Digestive Tract Cancers—The p53 Antibody Connection
JAMA Network Open
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Effect of Vitamin D Supplements on Relapse or Death in a p53-Immunoreactive Subgroup With Digestive Tract Cancer: Post Hoc Analysis of the AMATERASU Randomized Clinical Trial
JAMA Network Open
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Adjuvant immunotherapy with nivolumab versus observation in completely resected Merkel cell carcinoma (ADMEC-O): disease-free survival results from a randomised, open-label, phase 2 trial
The Lancet
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Should adjuvant nivolumab be used in surgically resected Merkel cell carcinoma patients?
The Lancet
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Reexamining Time From Breast Cancer Diagnosis to Primary Breast Surgery
JAMA Surgery
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Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma
Nature Medicine
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Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1
Nature Medicine
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Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study
The Lancet Oncology
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Mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma
The Lancet Oncology
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Cancer Biosimilars—A Regulatory Success So Far, but Value Still to Be Determined
JAMA Oncology
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Characteristics of Clinical Trials Evaluating Biosimilars in the Treatment of Cancer: A Systematic Review and Meta-analysis
JAMA Oncology
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Building a Fit for Purpose Clinical Trials Infrastructure to Accelerate the Assessment of Novel Hematopoietic Cell Transplantation Strategies and Cellular Immunotherapies
Journal of Clinical Oncology
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Extending the Promise of Chimeric Antigen Receptor T-Cell Therapy Beyond Targeting CD19+ Tumors
Journal of Clinical Oncology
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Adoptive T-Cell Therapy for Epstein-Barr Virus–Related Lymphomas
Journal of Clinical Oncology
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Optimizing Donor Choice and GVHD Prophylaxis in Allogeneic Hematopoietic Cell Transplantation
Journal of Clinical Oncology
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Immune Biology of Acute Myeloid Leukemia: Implications for Immunotherapy
Journal of Clinical Oncology
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Autologous Stem Cell Transplantation in the Management of Relapsed Non-Hodgkin Lymphoma
Journal of Clinical Oncology
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Biology in Practice: Harnessing the Curative Potential of the Immune System in Lymphoid Cancers
Journal of Clinical Oncology
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Vaccination as Immunotherapy in Hematologic Malignancies
Journal of Clinical Oncology
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Immunotherapy of Acute Lymphoblastic Leukemia and Lymphoma With T Cell–Redirected Bispecific Antibodies
Journal of Clinical Oncology
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How I Manage: Pathophysiology and Management of Toxicity of Chimeric Antigen Receptor T-Cell Therapies
Journal of Clinical Oncology
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Biology of Disease Relapse in Myeloid Disease: Implication for Strategies to Prevent and Treat Disease Relapse After Stem-Cell Transplantation
Journal of Clinical Oncology
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Defining the Role of Donor Lymphocyte Infusion in High-Risk Hematologic Malignancies
Journal of Clinical Oncology
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Is There Still a Role for Allogeneic Transplantation in the Management of Lymphoma?
Journal of Clinical Oncology
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Graft Versus Leukemia: Current Status and Future Perspectives
Journal of Clinical Oncology
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Maintenance with daratumumab or observation following treatment with bortezomib, thalidomide, and dexamethasone with or without daratumumab and autologous stem-cell transplant in patients with newly diagnosed multiple myeloma (CASSIOPEIA): an open-label, randomised, phase 3 trial
The Lancet Oncology
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Patient-reported Outcomes for Tolerability Assessment in Phase I Cancer Clinical Trials
Journal of the National Cancer Institute
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Underreporting of symptomatic adverse events in phase I clinical trials
Journal of the National Cancer Institute
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Adjuvant Zoledronate Therapy for Women With Breast Cancer—Effective Treatment or Fool’s Gold?
JAMA Oncology
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Prognosis of Patients With Early Breast Cancer Receiving 5 Years vs 2 Years of Adjuvant Bisphosphonate Treatment: A Phase 3 Randomized Clinical Trial
JAMA Oncology
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Practical implications to contemplate when considering radical therapy for stage III non-small-cell lung cancer
British Journal of Cancer
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Rationale for concurrent chemoradiotherapy for patients with stage III non-small-cell lung cancer
British Journal of Cancer
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Dossier
Menée sur 1 613 patients atteints d'un cancer du sein ou de la prostate, cette étude prospective évalue la toxicité d'une radiothérapie en fonction de variants génétiques
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Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer
JAMA Surgery
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Will Targeted Axillary Surgery Suffice for Adjuvant Treatment Decision-Making?
JAMA Surgery
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CEND-1: a game changer for pancreatic cancer chemotherapy?
The Lancet Gastroenterology & Hepatology
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Antibody-drug conjugates: when chemotherapy meets immuno-oncology
The Lancet Haematology
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Indatuximab ravtansine plus dexamethasone with lenalidomide or pomalidomide in relapsed or refractory multiple myeloma: a multicentre, phase 1/2a study
The Lancet Haematology
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Assessment of Coverage in England of Cancer Drugs Qualifying for US Food and Drug Administration Accelerated Approval
JAMA Internal Medicine
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Evaluation of the Clinical Benefit of Cancer Drugs Submitted for Reimbursement Recommendation Decisions in Canada
JAMA Internal Medicine
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Approval and Coverage of Cancer Drugs in England, Canada, and the US
JAMA Internal Medicine
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Another Milestone for Cryoablation on Its Way to Becoming the Standard of Care for Stage T1A Renal Cell Carcinoma
Radiology
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Percutaneous CT- and MRI-guided Cryoablation of cT1 Renal Cell Carcinoma: Intermediate- to Long-term Outcomes in 307 Patients
Radiology
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Characterizing the Risk of Vertebral Body Fractures in Patients Receiving Chemoradiotherapy for Esophageal Cancer
JAMA Network Open
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Association of Chemoradiotherapy With Thoracic Vertebral Fractures in Patients With Esophageal Cancer
JAMA Network Open
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Chemoradiotherapy plus a SMAC mimetic for locally advanced squamous cell carcinoma of the head and neck
The Lancet Oncology
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Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension
The Lancet Digital Health
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Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension
The Lancet Digital Health
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Guiding better design and reporting of AI-intervention trials
The Lancet Digital Health
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Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
The Lancet Oncology
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Cost-Effectiveness and Quality-Adjusted Survival of Watch-and-Wait after Complete Response to Chemoradiotherapy for Rectal Cancer
Journal of the National Cancer Institute
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Nonoperative Management of Rectal Cancer Shows Cost-Effectiveness, but Can Comparative Effectiveness Be Established?
Journal of the National Cancer Institute
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Combining microenvironment normalization strategies to improve cancer immunotherapy
Proceedings of the National Academy of Sciences
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Immunoactivating the tumor microenvironment enhances immunotherapy as predicted by integrative computational model
Proceedings of the National Academy of Sciences
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Assessment of Treatment Cost-effectiveness Using a Colorectal Cancer Mutation Profile
JAMA Network Open
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Cost-effectiveness Evaluation of Targeted Surgical and Endoscopic Therapies for Early Colorectal Adenocarcinoma Based on Biomarker Profiles
JAMA Network Open
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Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy
JAMA Oncology
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Is watch-and-wait ready for prime time? It depends on priming of the multidisciplinary care team
JAMA Oncology
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Deep Learning for Automated Contouring of Primary Tumor Volumes by MRI for Nasopharyngeal Carcinoma
Radiology
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Small Modifications in Technique May Yield Large Rewards After Lung Cancer Surgery
JAMA Surgery
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NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2–3, randomised, controlled trial
The Lancet Oncology
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Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial
JAMA Oncology
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Moving the Needle Forward With Locoregional Treatment in Unresectable Cholangiocarcinoma—The Jury Is Still Out
JAMA Oncology
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Effect of Vein-First vs Artery-First Surgical Technique on Circulating Tumor Cells and Survival in Patients With Non–Small Cell Lung Cancer: A Randomized Clinical Trial and Registry-Based Propensity Score Matching Analysis
JAMA Surgery
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Adjuvant chemotherapy for older patients with breast cancer: When is the pain worth the gain?
Journal of the National Cancer Institute
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Simulation of Chemotherapy Effects in Older Breast Cancer Patients With High Recurrence Scores
Journal of the National Cancer Institute
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Long-term results of stereotactic body radiation therapy in medically inoperable stage I non–small cell lung cancer
JAMA Oncology
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Stereotactic body radiation therapy for operable early-stage lung cancer: Findings from the NRG oncology RTOG 0618 trial
JAMA Oncology
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Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis
The Lancet Gastroenterology & Hepatology
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Watch and wait in rectal cancer: is it time to subclassify cT3?
The Lancet Gastroenterology & Hepatology
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Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
Cancer Cell
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Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial
The Lancet Gastroenterology & Hepatology
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Oral antibiotics for colon surgery: The questions remain the same, as do the answers
JAMA Surgery
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Microwave or radiofrequency ablation: clinically equivalent?
The Lancet Gastroenterology & Hepatology
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Association of the addition of oral antibiotics to mechanical bowel preparation for left colon and rectal cancer resections with reduction of surgical site infections
JAMA Surgery
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EGFR-TKI-associated interstitial pneumonitis in nivolumab-treated patients with non–small cell lung cancer
JAMA Oncology
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Immunotherapy and symptomatic radiation necrosis in patients with brain metastases treated with stereotactic radiation
JAMA Oncology
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Traitements localisés : découverte et développement (2)
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Menée sur un modèle murin, cette étude montre qu'une exposition à des rayonnements ionisants X peut, 4 semaines après, provoquer des altérations biologiques au niveau des mitochondries des cellules cardiaques
Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays
PLOS ONE
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Dossier
Menée auprès de 136 participants, cette étude évalue l'association entre des polymorphismes à simple nucléotide du gène MTHFR et le risque de pneumopathie radique chez des patients atteints d'un cancer du poumon et ayant reçu une radiothérapie thoracique
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Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer—We Must Do Better
Journal of Clinical Oncology
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Racial Disparities in Receipt of Guideline-Concordant Care for Early-Onset Colorectal Cancer in the United States
Journal of Clinical Oncology
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Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study
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Ultra-processed foods linked to higher mortality
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Sexual health-related psychological and emotional life after allogeneic haematopoietic stem-cell transplantation
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Sexually transmitted infections in the context of haematological malignancies
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Sexual health and emotional wellbeing of adolescent and young adult survivors of haematological malignancies
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Sexual health and emotional wellbeing of patients with haematological malignancies: general review
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Let's talk about sex and haematopoietic stem-cell transplantation
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Social Determinants of Health and Informed Consent Comprehension for Pediatric Cancer Clinical Trials
JAMA Network Open
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Clinical Benefit, Price, and Uptake for Cancer Biosimilars vs Reference Drugs in China: A Systematic Review and Meta-Analysis
JAMA Network Open
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Are Cancer Biosimilars Similar and Significant Enough to Deserve More Attention?
JAMA Network Open
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Opportunities to Advance Equity Through Informed Consent Discussions
JAMA Network Open
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Cannabinoids for symptom management in children with cancer: A systematic review and meta-analysis
Cancer
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Cannabinoids for symptom management in children with cancer: It’s complicated
Cancer
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Groundshot: a pan-European, patient-centred, and data-driven approach to tackling cancer
The Lancet Oncology
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European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission
The Lancet Oncology
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The impact of GDPR on data sharing for European cancer research
The Lancet Oncology
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Addressing health-related quality of life inequities in cancer: where do we go from here?
Journal of the National Cancer Institute
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Health-Related Quality of Life by Race, Ethnicity, and Country of Origin among Cancer Survivors
Journal of the National Cancer Institute
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Challenges in Assessing the Cost-effectiveness of Cancer Immunotherapy
JAMA Network Open
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Cost-effectiveness of Pembrolizumab as a Second-Line Therapy for Hepatocellular Carcinoma
JAMA Network Open
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Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials
BMJ
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Cost of colorectal cancer care: sufficient to inform cancer policy?
The Lancet Gastroenterology & Hepatology
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The economic burden of colorectal cancer across Europe: a population-based cost-of-illness study
The Lancet Gastroenterology & Hepatology
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The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
The Lancet Oncology
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Association Between African American Race and Clinical Outcomes in Men Treated for Low-Risk Prostate Cancer With Active Surveillance
JAMA
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Oncology nursing workforce: challenges, solutions, and future strategies
The Lancet Oncology
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Global childhood cancer survival estimates and priority-setting: a simulation-based analysis
The Lancet Oncology
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Neuronal Protection for Chemotherapy Neuropathy Prevention?
Journal of the National Cancer Institute
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Quantifying survival disparities among children diagnosed with cancer on a global scale
The Lancet Oncology
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The Effects of Ganglioside-Monosialic Acid in Taxane-induced Peripheral Neurotoxicity in Patients with Breast Cancer: A Randomized Trial
Journal of the National Cancer Institute
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The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet Gastroenterology & Hepatology
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Resource Utilization and Costs in Adolescents Treated for Cancer in Pediatric vs Adult Institutions
Journal of the National Cancer Institute
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Does Treatment Setting Matter? Evaluating Resource Utilization for Adolescents Treated in Pediatric vs Adult Cancer Institutions
Journal of the National Cancer Institute
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Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet
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Long-term Peripheral Neuropathy in Breast Cancer Patients Treated With Adjuvant Chemotherapy: NRG Oncology/NSABP B-30
Journal of the National Cancer Institute
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Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review
Journal of the National Cancer Institute
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Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada
JAMA Oncology
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Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database
The Lancet Oncology
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Treatment of colorectal peritoneal metastases requires multidisciplinary efforts
The Lancet Oncology
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Physiologic frailty in nonelderly hematopoietic cell transplantation patients: Results from the bone marrow transplant survivor study
JAMA Oncology
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Traitements systémiques : applications cliniques (3)
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Mené sur 519 patients atteints d'une leucémie myéloïde chronique, cet essai de phase III (DASISION) compare, après une durée de suivi de 24 mois, les effets de l'imatinib et du dasatiinib du point de vue des critères de réponse cytogénétique complète et de réponse moléculaire majeure
Dasatinib or imatinib in newly diagnosed chronic phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)
Blood
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Menée sur 354 patients atteints d'un myélome multiple, cette étude évalue les effets d'un traitement à base de bortezomib, avant et après une greffe autologue de cellules souches, en fonction de la présence d'une délétion du chromosome 17p13
Administration of bortezomib before and after autologous stem-cell transplantation improves outcome in multiple myeloma patients with deletion 17p
Blood
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Mené sur 724 patientes atteintes d'un cancer avancé du sein HR+, cet essai de phase III évalue les effets de l'ajout d'everolimus, un inhibiteur de mTOR, à l'exémestane (critère principal de jugement : survie sans progression)
Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer
New England Journal of Medicine
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Traitements systémiques : découverte et développement (9)
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Menée sur trois modèles murins de cancer, cette étude montre qu'une petite molécule inhibitrice de la voie PI3K est susceptible d'augmenter les effets d'une immunothérapie
Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T-cells that mediate rejection of murine tumors
Cancer Research
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Menée sur 699 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë et traités à l'aide de méthotrexate, cette étude montre que des variants rares du gène SCO1B1 sont associés à une toxicité importante induite par une faible clairance du médicament
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
Genome Research
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Menée in vitro et à l'aide de xénogreffes, cette étude suggère que le selumetinib et l'erlotinib, des inhibiteurs de la voie MEK/ERK, devraient faire l'objet d'essais cliniques pour le traitement d'un carcinome ovarien à cellules claires
MEK 1/2 Inhibitor selumetinib (AZD6244) Inhibits Growth of Ovarian Clear Cell Carcinoma in a PEA-15-dependent Manner in a Mouse Xenograft Model
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Menée in vitro, cette étude identifie un mécanisme par lequel la protéine Notch1 régule l'expression d'une protéine associée à une multirésistance médicamenteuse, ABCC1/MRP1
Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells
Proceedings of the National Academy of Sciences
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Menée in vitro et in vivo, cette étude suggère que le ganetespib, un inhibiteur de la protéine de choc thermique Hsp90, a un meilleur profil d'activité antitumorale et de toxicité que les inhibiteurs de Hsp90 de première et deuxième génération
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy
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Cettte étude met en évidence le rôle de la dopamine dans la normalisation du réseau vasculaire de tumeurs de la prostate et du côlon et suggère qu'un agoniste de la dopamine ou de son récepteur D2 pourrait être une option thérapeutique dans certains types de cancer
Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Krüppel-like factor-2 expression in tumor endothelial cells
Proceedings of the National Academy of Sciences
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Menée in vitro et in vivo, cette étude identifie le rôle de divers micro-ARNs dans l'apparition d'une résistance au gefitinib pour le traitement d'un cancer du poumon non à petites cellules
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
Nature Medicine
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Mené sur 417 patientes atteintes d'un cancer du sein HER2+, cet essai de phase II évalue deux traitements néoadjuvants, l'un combinant pertuzumab, ou trastuzumab, et docétaxel, l'autre combinant pertuzumab et trastuzumab sans chimiothérapie
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial
The Lancet Oncology
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Menée in vitro et in vivo, cette étude évalue l'activité antitumorale d'un composé appelé AZD8055, un inhibiteur de mTOR, dans les leucémies myéloïdes aiguës
The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
Leukemia
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